Indian Winter Cherry Root (aka Indian Ginseng) Stimulating Immunity In Mice:
Another study from Amala Cancer Research Center, India, suggested that administration of an extract from the powdered root of the plant Withania somnifera was found to stimulate immunological activity in Babl/c mice.
Immuno-modulatory Effect Of Indian Winter Cherry:
Aggarwal et al studied immunomodulatory activity of Withania somnifera extract in experimental immune inflammation. A protective effect in cyclophosphamide-induced myelosuppression was observed in animals treated WS extract, revealing a significant increase in white blood cell counts and platelet counts.
Cyclophosphamide-induced immunosuppression was counteracted by treatment with WS2, revealing significant increase in hemagglutinating antibody responses and hemolytic antibody responses towards sheep red blood cells.
Agarwal R, Diwanay S, Patki P, Patwardhan B.
Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, India.
Withania somnifera as Useful In Aging & Copper Induced Conditions:
Ashwagandha was investigated for copper induced lipid peroxidation and anti-oxidant enzymes in Wistar rats. Glutathione peroxidase GPx activity usually decreases in the spinal cord as the rat becomes aged. Ashwagandha treatment restored GPx activity and inhibited lipid peroxidation in dose dependent manner.
Copper induced lipid peroxidation and oxidative protein modification were inhibited by Withania somnifera. These benefits are similar to those induced by Superoxide dismutase and mannitol. So it was concluded that Ashwagandha might have role in aging and copper induced physiological or pathological conditions.
Gupta SK, Dua A, Vohra BP.
Department of Zoology, Kurukshetra University, Haryana, India. (Drug Metabol. Drug Interact. 2003:19(3) 211-12)
Ashwagandha Helping In Chronic Fatigue Syndrome:
This study reported the effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number of studies have shown that oxidative stress may be involved in its pathogenesis.
Co-administration of antioxidants carvedilol, melatonin, W. somnifera, quercetin or St. John's wort significantly reduced lipid peroxidation and restored the GSH levels decreased by chronic swimming in mice.
Further, the treatment increased levels of SOD in the forebrain and of catalase. The findings strongly suggest that oxidative stress plays a significant role in the pathophysiology of CFS and that antioxidants could be useful in the treatment of CFS.
Singh A, Naidu PS, Gupta S, Kulkarni SK.
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.